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It is possible to use Oracle database tables in the R statistical software. And this is a very useful approach (if you know R's capabilities). The fact that you are on this blog now may means that you had no success trying to use tables in R and that you received ORA-12541 once more. To solve this problem, you can omit the next paragraph. However, for getting started with Oracle 12c and R you should take a look at the documentation provided by Oracle. Clear and brief it says that you have to do the following things to use Oracle database in R: Install the Oracle Instant Client if you don't have already from http://www.oracle.com/technetwork/database/features/instant-client/ Install Oracle's R distribution (ORD) from https://oss.oracle.com/OR Modify the PATH variable for the  path of Instant Client Set the environment variable OCI_LIB64 with the path to the Instant Client Install ORE Client Package for R from http://www.oracle.com/technetwork/database/options/advanced-